Protein Modification Reagents
Medchemexpress LLC M-PEG-DSPE sodium | 95.0% | 3000 (average) | 25 MG
m-PEG-DSPE sodium (MW 3000) is a methoxy polyethylene glycol-distearoylphosphatidylethanolamine (PEG-lipid) provided as the sodium salt for use in drug delivery research. It is formulated to act as a surface-modifying lipid that improves colloidal stability and tissue targeting when incorporated into liposomes or nanoparticles.
- Provides hydrophilic PEG coating to reduce protein adsorption and extend circulation time.
- Average molecular weight of 3000 for predictable PEG chain length.
- Solid, white to off-white material suitable for formulation.
- High purity (95.0%) for reproducible experimental results.
- Compatible with nanoparticle and liposome formulation workflows.
- Store sealed at -20°C; solvent storage guidance for longer-term stability.
Medchemexpress LLC Fmoc-NH-(PEG)6-CH2CH2COOH | 882847-34-9 | 99.3% | 575.65 | C30H41NO10 | 500 MG
Fmoc-NH-(PEG)6-CH2CH2COOH is an Fmoc-protected PEG6 propionic acid linker used as a cleavable linker in the synthesis of antibody-drug conjugates (ADCs). It is characterized by high purity, defined molecular properties, and recommended cold storage for stability.
- Cleavable linker for antibody-drug conjugation.
- Fmoc-protected amine functionality for stepwise synthesis.
- PEG6 spacer provides hydrophilicity and flexibility.
- High purity: 99.3%.
- Molecular weight 575.65; formula C30H41NO10.
- Available in multiple sizes: 100 mg, 500 mg, 1 g, 5 g, 10 g.
- Appearance: colorless to light yellow liquid; density 1.202 ± 0.06 g/cm3.
- Storage: -20°C (3 years) or 4°C (2 years) in pure form; in solution -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC m-PEG6-CH2CH2COOH | 874208-91-0 | >=95.0% | 368.42 g/mol | C16H32O9 | 500 MG
m-PEG6-CH2CH2COOH is a polyethylene glycol (PEG)-based PROTAC linker terminated with a carboxylic acid. It provides a six-unit PEG spacer for flexible linkage in conjugation chemistry and is supplied as a solid for synthetic use. Typical quality: ≥95.0% purity; molecular weight 368.42 g/mol; formula C16H32O9; CAS 874208-91-0.
- Peg6 spacer with terminal carboxylic acid for conjugation.
- Suitable for use as a PROTAC or linker building block in medicinal chemistry.
- Available in multiple pack sizes, including 500 MG.
- High purity for synthetic applications (≥95.0%).
- Solid form with defined molecular weight (368.42 g/mol).
Medchemexpress LLC Pc biotin-peg3-nhs ester | 2353409-93-3 | 95.0% | 840.89 g/mol | C36H52N6O15S | 5 MG
PC Biotin-PEG3-NHS ester is a cleavable three-unit polyethylene glycol (PEG3) linker bearing a biotin tag and an N-hydroxysuccinimide (NHS) ester for coupling to primary amines, used in linker and biotinylation chemistries.
- Cleavable PEG3 linker suitable for conjugation chemistries.
- Contains an NHS ester for efficient reaction with primary amines.
- Biotin tag enables affinity capture and detection.
- Supplied in small, research-scale quantities for synthetic workflows.
- Stable when stored as recommended; purity suitable for research use.
STA PHARMACEUTICAL US LLC Fmoc-NH-PEG6-CH2CH2COOH | 50 g | CAS 882847-34-9 | MDL MFCD06656474
Fmoc-NH-PEG6-CH2CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 50 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 882847-34-9
- MDL: MFCD06656474
- InChIKey: HEGZERUHBVYZPH-UHFFFAOYSA-N
- Molecular Weight: 575.655
- Molecular Formula: C30H41NO10
- Purity: ≥95%
- Container Type: 250 mL HDPE
- Pack Size: 50 g
- Net Weight: 50 g
- Gross Weight: 89.8 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22-heptaoxa-4-azapentacosan-25-oic acid
- SMILES: O=C(CCOCCOCCOCCOCCOCCOCCNC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)O
Medchemexpress LLC m-PEG-DMG (MW 2000) | 1019000-64-6 | 98.0% | 2000 (average) | No fixed chemical formula - polymeric m-PEG-DMG (average MW 2000) | 10 MG
m-PEG-DMG (MW 2000) is a methoxy-terminated polyethylene glycol conjugated to dimyristoyl glycerol, provided as a solid PEGylated lipid for formulation research. It is used to prepare liposomes and lipid nanoparticles for drug delivery studies, and is supplied at an average molecular weight of 2000 with high purity for reliable experimental results.
- PEGylated lipid for liposome and lipid nanoparticle formulation.
- Average molecular weight 2000 for consistent PEG chain length.
- High purity (~98.0%) suitable for research applications.
- White to off-white solid, easy to handle in laboratory settings.
- Stable when stored as a powder at low temperatures for extended shelf life.
eMolecules Methyltetrazine-PEG8-amine HCl salt | | | 500mg
Broadpharm | Methyltetrazine-PEG8-amine HCl salt | 500mg | 563055151 | BP-24058 | 98.000 | | | 576.090 | C25H42ClN5O8
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Cayman Chemical DPPE-MPEG 2000 5mg
A PEGylated form of DPPE; has been used in the synthesis of anionic liposomes for drug redistribution and toxicity prevention
Medchemexpress LLC Dspe-peg-amine ammonium | 474922-26-4 | 99.5% | 1,000 g/mol (average) | (C2H4O)nN2O10P.NH3 | 250 MG
DSPE-PEG-Amine (average MW 1,000, ammonium salt) is a PEGylated phosphoethanolamine lipid bearing a terminal primary amine. It is formulated for incorporation into liposomes, micelles, and other nanoparticle systems to introduce reactive surface amines for covalent conjugation, targeting ligand attachment, and to provide steric stabilization in delivery research.
- Provides a primary amine terminus for bioconjugation.
- Incorporates into lipid bilayers and micelles for surface functionalization.
- Provides PEG steric stabilization to improve circulation and reduce aggregation.
- Suitable for covalent coupling to proteins, dyes, or targeting ligands.
- Average molecular weight 1,000 g/mol, polymeric PEG repeat unit.
- Recommend frozen, sealed storage and protection from moisture.
Medchemexpress LLC Dspe-peg-nhs | 98.0% | 2000 (average) | 10 MG
DSPE-PEG-NHS, MW 2000 is a PEG-modified phospholipid with an N-hydroxysuccinimide (NHS) activated ester for conjugation to primary amines. It is used to modify liposome surfaces and other lipid-based nanoparticles, providing a lipid anchor with a PEG spacer to improve colloidal stability and enable surface functionalization for drug delivery research.
- NHS-activated ester for efficient amine conjugation.
- DSPE lipid anchor for stable membrane insertion.
- PEG spacer (average molecular weight 2000) provides steric stabilization and reduced opsonization.
- High purity (~98.0%) suitable for research applications.
- Solid, white to off-white form; store at -20 °C sealed away from moisture.
- Available in small vials (e.g., 10 MG) for lab-scale work.
Selleck Chemical LLC (S.R.S)-AHPC-PEG4-NH2 hydrochloride S3502-5mg
(S R S)-AHPC-PEG4-NH2 hydrochloride (VH032-PEG4-NH2 hydrochloride VHL Ligand-Linker Conjugates 4 hydrochloride E3 ligase Ligand-Linker Conjugates 7) is a PROTAC E3 ligase ligand-linker conjugate that incorporates the (S R S)-AHPC based VHL ligand and 4-unit PEG linker
Medchemexpress LLC (2S,4R)-1-((S)-17-amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecanoyl)-4-hydroxy | 2010159-57-4 | 95.6% | 663.83 g/mol | C32H49N5O8S | 10 MG
(S,R,S)-AHPC-PEG4-NH2 is a VHL E3 ligase ligand-linker conjugate used as a building block in proteolysis-targeting chimera (PROTAC) synthesis. It couples an (S,R,S)-AHPC-derived VHL ligand to a four-unit polyethylene glycol (PEG4) linker terminating in a primary amine, providing a conjugation handle for attachment to target ligands.
- VHL E3 ligase ligand-linker conjugate for PROTAC assembly
- PEG4 linker with terminal primary amine for straightforward conjugation
- Molecular weight 663.83 g/mol
- Typical purity 95.6%; select batches up to 99.51%
- Highly soluble in DMSO (170 mg/mL); ultrasonic agitation recommended
- Powder storage: -20°C (3 years) or 4°C (2 years); in solvent: -80°C (2 years)
Medchemexpress LLC DBCO-PEG5-NHS ester | 2144395-59-3 | MFCD22380747 | 95.0% | 693.74 | C36H43N3O11 | 10 MG
DBCO-PEG5-NHS ester is a DBCO-functionalized PEG5 N-hydroxysuccinimide (NHS) ester used as a bioconjugation linker. It couples to primary amines via the NHS ester and enables copper-free, strain-promoted azide-alkyne cycloaddition through the DBCO moiety, making it suitable for linker synthesis and click-based conjugations in research applications.
- Reacts efficiently with primary amines via the NHS ester.
- Enables copper-free click chemistry using DBCO for strain-promoted azide-alkyne cycloaddition.
- Useful for antibody-drug conjugate and PROTAC linker assembly.
- Supplied as a colorless to light yellow oil with high purity (~95.0%).
- Available in small research quantities suitable for synthesis and labeling.